The beginnings of Nanobiotechnology for Diagnostics (Nb4D) were in the early 2000s. Initially the group, under the name of Applied Molecular Receptor group (AMRg), consisted of two staff researchers and 3 or 4 PhD students. By then, the aim of the group was the production of natural tailored molecular receptors (antibodies).

The rational design of these biomolecules allowed the production of receptors with high affinity and specificity against a large set of target compounds. Firstly, we focused our research on the detection of environmental pollutants. The use of rationalised molecular modeling, added to the great experience gained over the years, helping us to design useful tools for the selection and preparation of the most suitable immunizing biomolecules.

Four years later, we began researching in other fields such as food safety. Thanks to several Spanish and European projects, we were able to produce specific antibodies and develop immunochemical techniques for the analysis of a variety of antibiotics. Some of these antibodies have been patented, and nowadays represent one of our top achievements. By this time, we were interested in molecular imprinted polymers (MIPS) as an alternative to the natural receptors. The idea of these synthetic receptors was to produce a polymeric network around the targeted analyte through non-covalent interactions. The removal of the analyte allowed the creation of specific cavities.

The ability to produce receptors with higher additional values (i.e. specificity) allowed us access into the biosensor field. Nowadays we are experts on the production of bioconjugates, immobilization of immunoreceptors on different transducer surfaces, and on the preparation of different biohybrid materials.

During this time, more than 40 people have participated actively in some of the research projects of the group with enthusiastic dedication. AMRg has directed more than 15 doctoral theses and has published more than 150 articles in international journals. Finally, all these great efforts and knowledge have allowed us to license several patents.
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